Sylvie wishes the anti-depressants had been around when she was in her early twenties, not only to rescue her from the dark tunnels that came when her brother first got sick, but also to keep her from fucking all those assholes.
Francesca Lia BlockTags: sex drugs depression antidepressants
Even if it were possible to cast my horoscope in this one life, and to make an accurate prediction about my future, it would not be possible to 'show' it to me because as soon as I saw it my future would change by definition. This is why Werner Heisenberg's adaptation of the Hays Office—the so-called principle of uncertainty whereby the act of measuring something has the effect of altering the measurement—is of such importance. In my case the difference is often made by publicity. For example, and to boast of one of my few virtues, I used to derive pleasure from giving my time to bright young people who showed promise as writers and who asked for my help. Then some profile of me quoted someone who disclosed that I liked to do this. Then it became something widely said of me, whereupon it became almost impossible for me to go on doing it, because I started to receive far more requests than I could respond to, let alone satisfy. Perception modifies reality: when I abandoned the smoking habit of more than three decades I was given a supposedly helpful pill called Wellbutrin. But as soon as I discovered that this was the brand name for an antidepressant, I tossed the bottle away. There may be successful methods for overcoming the blues but for me they cannot include a capsule that says: 'Fool yourself into happiness, while pretending not to do so.' I should actually want my mind to be strong enough to circumvent such a trick.
Christopher HitchensTags: life perception future happiness reality writers virtues smoking depression self-delusion assistance mentorship measurement antidepressants horoscopes bupropion hays-office publicity soothsaying uncertainty-principle werner-heisenberg
I'm generally a happy person -with the help of antidepressants, that is- so there is something to be said for surrounding myself with happy people.
Rachel MachacekTags: happiness happy antidepressants
How does your patient, doctor?
Doctor: Not so sick, my lord, as she is troubled with thick-coming fancies that keep her from rest.
Macbeth: Cure her of that! Canst thou not minister to a mind diseased, pluck from the memory a rooted sorrow, raze out the written troubles of the brain, and with some sweet oblivious antidote cleanse the stuffed bosom of that perilous stuff which weighs upon her heart.
Doctor: Therein the patient must minister to himself.
Tags: sorrow depression heartbreak psychiatry psychotherapy mental-health antidepressants
According to an article in the Washington Post: The Food and Drug Administration has repeatedly urged antidepressant manufacturers not to disclose to physicians and the public that some clinical trials of the medications in children found that drugs were no better than sugar pills, according to documents and testimony released at a congressional hearing yesterday. Regulators supressed the negative information on the grounds that it might scare families and physicians away from the drugs, according to testimony by drug company executives. For at least three medications, they said, the FDA blocked the companies' plans to reveal the negative studies in drug labels.
Irving KirschTags: negative antidepressants studies
Our analyses of the FDA data showed relatively little difference between the effects of antidepressants and the effects of placebos. Indeed, the effects were so small that they did not qualify as clinically significant. The drug companies knew how small the effect of their medications were compared to placebos, and so did the FDA and other regulatory agencies. The companies found various ways to make the data seem more favorable to their products, and the FDA helped them keep their negative data secret. In fact, in some instances, the FDA urged the companies to keep negative data hidden, even when the companies wanted to reveal them. My colleagues and I hadn't really discovered anything new. We had merely revealed their 'dirty little secret'.
Irving KirschTags: secret bad antidepressants fda drug-companies ineffective
Physicians do not systematically prescribe placebos to their patients. Hence they have no way of comparing the effects of the drugs they prescribe to placebos. When they prescribe a treatment and it works, their natural tendency is to attribute the cure to the treatment. But there are thousands of treatments that have worked in clinical practice throughout history. Powdered stone worked. So did lizard's blood, and crocodile dung, and pig's teeth and dolphin's genitalia and frog's sperm. Patients have been given just about every ingestible - though often indigestible - substance imaginable. They have been 'purged, puked, poisoned, sweated, and shocked', and if these treatments did not kill them, they may have made them better.
Irving KirschTags: history antidepressants treatments
Depression, we are told over and over again, is a brain disease, a chemical imbalance that can be adjusted by antidepressant medication. In an informational brochure issued to inform the public about depression, the US National Institute for Mental Health tells people that 'depressive illnesses are disorders of the brain' and adds that 'important neurotransmitters - chemicals that brain cells use to communicate - appear to be out of balance'. This view is so widespread that it was even proffered by the editors of PLoS [Public Library of Science] Medicine in their summary that accompanied our article. 'Depression,' they wrote, 'is a serious medical illness caused by imbalances in the brain chemicals that regulate mood', and they went on to say that antidepressants are supposed to work by correcting these imbalances.
The editors wrote their comment on chemical imbalances as if it were an established fact, and this is also how it is presented by drug companies. Actually, it is not. Instead, even its proponents have to admit that it is a controversial hypothesis that has not yet been proven. Not only is the chemical-imbalance hypothesis unproven, but I will argue that it is about as close as a theory gets in science to being dis-proven by the evidence.
Tags: depression antidepressants
Psychotherapy works for the treatment of depression, and the benefits are substantial. In head-to-head comparisons, in which the short-term effects of psychotherapy and antidepressants are pitted against each other, psychotherapy works as well as medication. This is true regardless of how depressed the person is to begin with.
Psychotherapy looks even better when its long-term effectiveness is assessed. Formerly depressed patients are far more likely to relapse and become depressed again after treatment with antidepressants than they are after psychotherapy. As a result, psychotherapy is significantly more effective than medication when measured some time after treatment has ended, and the more time that has passed since the end of treatment, the larger the difference between drugs and psychotherapy.
Tags: psychotherapy better antidepressants
For people who are depressed, and especially for those who do not receive enough benefit from medication of for whom the side effects of antidepressants are troubling, the fact that placebos can duplicate much of the effects of antidepressants should be taken as good news. It means that there are other ways of alleviating depression. As we have seen, treatments like psychotherapy and physical exercise are at least as effective as antidepressant drugs and more effective than placebos. In particular, CBT has been shown to lower the risk of relapsing into depression for years after treatment has ended, making it particularly cost effective.
Irving KirschTags: depression psychotherapy antidepressants good-news cognitive-behavior-therapy placebo
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